Process for the preparation of thiosulfenyl carbamoyl halides

ABSTRACT

N-Thiosulfenylcarbamoyl halide compositions are useful intermediates in the production of carbamate compositions.

This invention relates to novel carbamoyl halide compositions and to their preparation.

The novel compositions of this invention are compounds corresponding to the following general formula: ##STR1## wherein: X may be fluorine or chlorine

R may be lower alkyl, lower alkenyl or lower alkyl substituted with one or more chloro, bromo, fluoro, nitro or cyano substituents or phenyl or lower phenyl alkyl either unsubstituted or substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl, lower haloalkyl or lower alkoxy substituents.

R₁ may be alkyl, alkenyl, cycloalkyl, bicycloalkyl, cycloalkenyl or bicycloalkenyl or lower phenylalkyl or phenyl or lower phenylalkyl or phenyl substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl, lower alkoxy, lower haloalkyl, lower alkanoyl or carbamoyl substituents.

These compounds are valuable intermediates which are useful in the preparation of insecticidal compositions. Compositions of this invention can be reacted with oxime compositions such as 1-methylthioacetaldoxime, as more fully described in my copending U.S. Patent Application Ser. No. 486,632 filed concurrently herewith, to produce insecticidal and miticidal compositions.

The novel compositions of this invention can be prepared in a variety of ways. One preferred method of preparation is by the process shown in the following general reaction scheme: ##STR2##

They may also be prepared by the following process: ##STR3##

A third method of producing these compositions is as follows: ##STR4##

In each of the three general reaction schemes shown above X, R and R₁ are as defined above.

These reactions are preferably carried out in an aprotic solvent such as toluene, benzene, xylene, dioxane methylene chloride or the like.

These reactions are carried out in the presence of an organic base, preferably a tertiary amine such as triethyl amine.

Illustrative of the new compositions of matter which can be prepared by the above processes are the following:

N-Methyl-N(methylthiosulfenyl)carbamoyl fluoride

N-Ethyl-N(methylthiosulfenyl)carbamoyl fluoride

N-Butyl-N(methylthiosulfenyl)carbamoyl fluoride

N-Allyl-N(methylthiosulfenyl)carbamoyl fluoride

N-Phenyl-N(methylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(methylthiosulfenyl)carbamoyl chloride

N-Methyl-N(ethylthiosulfenyl)carbamoyl chloride

N-Methyl-N(propylthiosulfenyl)carbamoyl chloride

N-Methyl-N(isopropylthiosulfenyl)carbamoyl fluoride

N-Methyl-N-2(2-methylpropanethiosulfenyl)carbamoyl fluoride

N-Methyl-N(n-octylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(dodecylthiosulfenyl)carbamoyl fluoride

N-Methyl-N-(octadecylthiosulfenyl)carbamoyl fluoride

N-Methyl-N-(t-octylthiosulfenyl)carbamoyl fluoride

N-Phenyl-N-2(2-methylpropanethiosulfenyl)carbamoyl chloride

N-Allyl-N-(butylthiosulfenyl)carbamoyl chloride

N-p-chlorophenyl-N(methylthiosulfenyl)carbamoyl fluoride

N-(2-Chloroethyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-(2-Nitroethyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-(3-Cyanopropyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-Benzyl-N(methylthiosulfenyl)carbamoyl fluoride

N-(4-Chlorobenzyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-(3-Nitrophenyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-(4-Methylphenyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-(4-Methoxyphenyl)-N(Methylthiosulfenyl)carbamoyl fluoride

N-(4-Trifluoromethylphenyl)-N(methylthiosulfenyl)-carbamoyl fluoride

N-(4-Cyanophenyl)-N(methylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(allylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(cyclopentylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(bicyclodecylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(benzylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-bromobenzylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(3-nitrophenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-cyanophenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-t-butylphenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-methoxyphenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-trifluoromethylphenylthiosulfenyl)-carbamoyl fluoride

N-Methyl-N(2,4-dichlorophenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-methylphenylthiosulfenyl)carbamoyl fluoride

N-Methyl-N(4-dimethylcarbamoylphenylthiosulfenyl)-carbamoyl fluoride

N-Methyl-N(4-acetylphenylthiosulfenyl)carbamoyl fluoride

The following examples are provided to more clearly illustrate the procedures for producing the novel compositions of this invention.

EXAMPLE I Preparation of N-Methyl-N(methylthiosulfenyl)carbamoyl Fluoride (Method I)

To a solution of 7.59 g hydrogenfluoride in 50 ml toluene, cooled to -50° C, was added dropwise with stirring 21.62 g methylisocyanate. After stirring for 1 hour 55.0 g methylthiosulfenyl chloride in 200 ml toluene was added followed by dropwise addition of 38.3 g of triethylamine. The reaction temperature during the addition of base was maintained between 0° and 10° C. Stirring continued for additional one hour after the addition of base was completed. The precipitated salt was filtered off and the filtrate concentrated under vacuo. Distillation yielded 16.7 g of pure product b.p. 42° C/0. 2 Torr, N_(D) ²⁴ 1.5096.

Calc'd. for C₃ H₆ FNOS₂ : C, 23.22; H; 3.89; N; 9.02; Found: C, 23.39; H; 4.18; N; 8.75. IR (Neat) 5.58 (C=O), 7.05, 7.7, 8.4, 8.6, 9.2, 9.35, 10.6, 13.4 and 14.35μ. NMR (CDCl₃), δ 2.69, (singlet), 3H, CH₃ S, 3.28, (doublet), J = 1.0 H_(z),3H, CH₃ N.

EXAMPLE II Preparation of N-Methyl-N(2-Methyl-2-Propanethiosulfenyl)Carbamoyl Fluoride (Method I)

To a solution of 231.08 N-methylcarbamoyl fluoride, (prepared in situ as before) in 600 ml toluene, cooled to 0° C was added 478.0 g 2-methyl-2-propanethiosulfenyl chloride dissolved in 1000 ml toluene. This was followed by dropwise addition of 303.0 g triethylamine in 1000 ml of toluene. Stirring was continued for an additional 2 hr. at 5° C. The precipitated salt was filtered off the filtrate concentrated. Wt. of reddish oil 577.0 g. b.p. 75°-80° C/0.5 Torr. N_(D) ²² 1.4983.

IR(Neat 5.6 (C=O), 6.9, 7.7, 8.65, 9.25, 9.4 (sh), 10.62 and 13.4μ NMR(CDCl₃) δ 1.4, (S), 9H, t-Bu; 3.23 (d), J=1.0H_(z), 3H, CH₃ N.

EXAMPLE III Preparation of N-Methyl-N-(n-Octylthiosulfenyl)Carbamoyl Fluoride (Method I)

Prepared as above by adding 25.2 g triethylamine to a solution of 48.0 g. n-octylthiosulfenylchloride and 19.26 g N-methylcarbamoyl fluoride. b.p. 110-118° C/0.2 Torr. N_(D) ²¹ 1.4900.

IR(Neat) 5.58 (C=O), 6.9-7.1 (broad), 7.7, 8.4, 8.6, 9.2-9.35 (broad), 10.4 (Sh), 10.58, 13.4, 13.9 and 14.3μ. NMR(CDCl₃), δ 0.88, (t), τ˜ 5.0 H_(z), 3H, CH₃ ; 1.1-1.9 (m), 12H, CH₂, 2.99, (t), J = 7.0 H₂, 3H, --CH₂ S--; 3.25, d, J_(HF) ˜1.0 H_(z), 3H, CH₃ N. Calc'd. for C₁₀ H₂₀ FNOS₂ C, 47.40; H, 7.96; N, 5.53; Found: C, 47.22; H; 7.27; N; 5.43.

EXAMPLE IV Preparation of N-Methyl-N(4-t-Butylphenylthiosulfenyl) Carbamoyl Fluoride (Method I)

To a solution of 5.5 g hydrogen fluoride in toluene cooled to -65° C was added dropwise with stirring 15.0 ml of methylisocyanate over a period of 20 minutes after stirring for 1.5 hr preshly prepared 4-t-butylphenylthiosulfenyl chloride (prepared from 36.2 g 4-butylphenol and 31.0 g sulfur dichloride in 800 ml ethyl ether) was added at -10° to 0° C over a period of 0.5 hr. After stirring overnight at ambient temperature, the salt was removed by filtration and the filtrate distilled. b.p. 122°-127° C/0.2 Torr.

IR(Neat) 5.6 (C=O) and other import peaks at 7--7, 9.3, 10.55, 12--12 and 13.4μ NMR(CDCl₃) δ 1.27, (S), 9H; 3.15, (d) δ 1.0 H_(z), 3H, 7.3-7.6 (m), 4H.

EXAMPLE V Preparation of N-Methyl-N(2,4-Dichlorophenylthiosulfenyl)-Carbamoyl Fluoride (Method II)

An essentially equimolar amount of N-methyl-N-chlorosulfenylcarbamoylfluoride in toluene solvent is added to 2,4-dichlorophenylthiol followed by dropwise addition of triethylamine, with stirring, until the reaction is complete. The product is separated and purified by the procedures described above.

EXAMPLE VI Preparation of N-Allyl-N(Butylthiosulfenyl)Carbamoyl Chloride (Method III)

An essentially equimolar amount of allyl amine and an equimolar amount of triethylamine is added slowly with stirring to a quantity of butyldithiochloride in toluene until the reaction is complete. The resulting salt precipitate is removed by filtration. An equimolar amount of triethylamine base is then added to the filtrate followed by the slow addition of phosgene until the reaction is complete. The resulting N-Allyl-N-(butylthiosulfenyl)carbamoyl chloride product is separated and purified by the procedure described above.

These compounds are valuable intermediates for the preparation of insecticidal compositions. Compounds of this invention can be reacted with oxime compounds in accordance with the following general reaction scheme: ##STR5## where R, R₁ and X are as described above and,

R₂ may be lower alkyl or lower alkyl substituted with one or more chloro, bromo, fluoro, nitro or cyano substituents or phenyl or lower phenyl alkyl either unsubstituted or substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl or lower alkoxy substituents.

R₃ my be alkyl, alkenyl, cycloalkyl, bicycloalkyl, cycloalkenyl, bicycloalkenyl or phenyl or lower phenyl alkyl either unsubstituted or substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl, lower alkoxy or lower haloalkyl substituents.

The reaction set forth above is preferably carried out in an aprotic solvent such as dioxane, toluene, xylene or benzene and in the presence of a base such as a tertiary amine or an alkaline earth base.

The following example is a more specific illustration of the use of the compounds of this invention in the preparation of pesticidally active compounds.

EXAMPLE VII 1-Methylthioacetaldehyde 0-([N-methyl-N-(2-methyl-2-propanethiosulfenyl)carbamoyl]oxime

To a solution of 2.83 g (0.027m) of 1-methylthioacetaldoxime and 11.15 g (0.027 m) of N-methyl-N-(2-methyl-2-propanethiosulfenyl)carbamoyl fluoride in 75 ml of dioxane, was added dropwise 2.72 g (0.027 m) of triethylamine. After stirring for 72 hours at ambient temperature the reaction mixture was concentrated under reduced pressure, it was diluted with water and extracted with ethyl acetate. The organic extract was washed with water, dried over magnesium sulfate and concentrated. Crystallized from isopropyl ether-hexane solution to afford a white solid -m.p. 67°-69° C. On recrystallization, m.p. 71°-73° C.

Calc'd for C₉ H₁₈ N₂ O₂ S₃ : C, 38.46: H, 6.40; N, 9.88; Found: C, 38.57; H, 6.20; N, 9.95.

The compound of Example VII was evaluated to determine its pesticidal activity against two-spotted mite (Tetranychus urticae Koch ) bean aphid (Aphis fabae Scop.); Southern Armyworm (Prodenia eridania, (Cram)); Mexican bean beetle (Epilachna varivestic, Muls.); and housefly (Musca domestica, L.) A suspension of the compound was prepared by dissolving one gram of the compound in 50 milliliters of acetone which contained 0.1 gram of an alkylphenoxy polyethoxyethylene surfactant. The resulting solution was successively diluted with water to provide a suspension containing 500 parts of the compound per million parts of final formulation.

The test insect and mite species were sprayed with 100 and 110 milliliters of the test compound formulation for approximately 25 seconds. The test species were then held for from one to three days at constant temperature and/or constant humidity after which the extent of mortality was recorded. The compound was found to exhibit excellent control of all of the test species. 

What is claimed is:
 1. A method of preparing a compound of the formula: ##STR6## which comprises reacting a compound of the formula: ##STR7## with a compound of the formula:

        X--S--S--R.sub.1                                                      

in the presence of an organic base, wherein: X is chlorine R is lower alkyl, lower alkenyl or lower alkyl substituted with one or more chloro, bromo, fluoro, nitro or cyano substituents or phenyl or lower phenyl alkyl either unsubstituted or substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl, lower haloalkyl or lower alkoxy substituents. R₁ is alkyl, alkenyl, cycloalkyl, bicycloalkyl, cycloalkenyl or bicycloalkenyl or lower phenylalkyl or phenyl; or lower phenylalkyl or phenyl substituted with one or more chloro, bromo, fluoro, nitro, cyano, lower alkyl, lower alkoxy, lower haloalkyl, lower alkanoyl or carbamoyl substituents.
 2. A method according to claim 1 wherein the reaction is conducted in an aprotic solvent.
 3. A method according to claim 1 wherein said organic base is a tertiary amine.
 4. A method according to claim 1 wherein R is lower alkyl.
 5. A method according to claim 1 wherein R₁ is alkyl.
 6. A method according to claim 1 wherein R is methyl and R₁ is methyl.
 7. A method according to claim 1 wherein R is methyl and R₁ is 2-methyl-2-propyl.
 8. A method according to claim 1 wherein R is methyl and R₁ is n-octyl. 